Research Projects

Assoc. Prof. Krassimira Todorova, PhD, DSc

Current Research Topics:

Prostate Cancerogenesis. Role of specific micro-RNAs in the epigenetic and transcriptional regulation of prostate cancer metastasis. Perturbation of Regulatory Gene network of miR-204 and miR-15 and transcriptional factors cMYB, RUNX2 and ETS1 in prostate cancer metastasis. Another tightly related trend of research is focused on the regulation of expression and the modes of action of prostate-specific fusion oncoproteins with regulatory function and poor prognosis association such as TMPRSS2:ERG.

Funding:

2011 - 2015 Project Leader, funded by National Science Fund, Bulgarian Ministry of Education and Science: Young Scientists Project Competition - “Gene regulatory networks involving miRNA, transcription factors and onco-fusion proteins in Prostate Cancerogenesis with diagnostic and therapeutic significance”

Patents:
1. Soren Hayrabedyan, Krassimira Todorova. Method and kit for detection of cancer fusion protein. Filled National Patent Office 2014. Currently pending.

Assoc. Prof. Soren Hayrabedyan, MD, PhD

Current Research Topics:

Role of innate immune receptors of the NOD family and inflammasomes (NALP3) in Sertoli cell biology and immunology, implications on male fertility. Epigenetic regulation of innate immunity receptors.

PreImplantationFactor^TM (PIF) synthetic transgene design and direct eukaryote expression. PIF ligand-receptor interaction with Kv1.3 and IDE