Main research topics

Laboratory Head: Professor Krassimira Olegova Todorova, PhD, DSc

Main Research Topics

Main Goal of the newly established Laboratory:

Research of the global changes at genome, transcriptome and proteome level implicated in the biological processes in normal and pathological conditions in reproductive system and related to reproduction and sexual development organs

Laboratory Activities:

1. Study of epigenetic regulation in reproductive and oncological phenomena.

2. Genomic and transcriptomic studies - nanopore-based 3rd generation sequencing, bioinformatics analysis of NGS data and deep sequencing library preparation.

3. Molecular modelling and molecular dynamics of ligand-receptor interactions implicated in reproduction, immunomodulation and oncology and their experimental validation.

4. Methods of exogenous and genomic expression of molecules important in embryogenesis, reproductive Immunology and oncogenesis.

5. Biomarkers - development of new methods for detection of fusion phenomena and validation of markers with diagnostic application

Lab Photos: