• Institute of Biology and Immunology of Reproduction
      "Acad. Kiril Bratanov"

      • IBIR-BAS projects 2008-2012

        IBIR-BAS projects 2008-2012

        Projects with additional financing from programs supported by EU, NATO, UNESCO a\and other international organizations

         

        Title of the research theme, leader

        Funding

        1.ReProForce  FP-7- REGPOT-2009-1 reinforcement of the research capacity of the bulgarian institute “biology and immunology of reproduction”.

        2009-2013, 1499181 euro

        2. COST Action FA0602 " Bioactive Food Components, Mitochondrial Function and Health"

        Prof. D.Kacheva

        Assoc. prof. E.Kistanova

        2007-2011

        20 000 euro - participation in the meetings, organization of the meeting in Sofia,

        short-term scientific mobility

        3. COST Action F1201 " Epigenetics and Periconception Environment - Periconception environment as an epigenomic lever for optimising food production and health in livestock"

        Prof. D.Kacheva

        Assoc. prof. E.Kistanova

        2012-2016

        till now 700 euro - participation in the meeting

        4.  NEAT , Network to enhance the use of economics in animal health education, research and policy making in Europe and beyond. LLP-1 -2012-1 UK-ERAZMUS- ENM;  LLP Programme (Lifelong learning

        GA-2012-3830/001-001

        Assoc. prof. B.Georgiev

        2012-2015

         

        till now 2700 euro

         

        The role of matrix metalloproteinases 2 and 9 and ADAMS phamily in pathophysiology of breast cancer in humnas.

        Assistant Prof. Rumen Kirilov Dimitrov, Assoc. Prof. P. Rashev

        Prof. Hans Donat

         

        2011-2013

         

        10 000 euro for consumables and travel

         

        Regional projects, e.g. South Eastern Europe (SEE) and non- European. Bilateral agreements between academies of sciences. These projects are on the base of equivalent without money exchange between Academies of Sciences  

         

        Expression of genes and proteins with a role in reproduction - biomarkers for infringements.

        PI from IBIR: Associate Professor Dr. Margarita Mollova with the Institute of Genetics, Czech Academy of Sciences

        2007-2010

         

        accommodation support, no funding for research activities

        Proteomics of seminal plasma from ram, boar and dog in relation to cryotolerance of spermatozoa of these species.

        PI form IBIR, Associate Professor Dr. Maria Ivanova-Kicheva with the Univ. off Warmia and Mazury, Poland

        2007-2010

        accommodation support, no funding for research activities

        Expression of genes and proteins with a role in reproduction - biomarkers for infringements.

        PI from IBIR: Assistant Professor Julieta Dineva with the Institute of Genetics, Czech Academy of Sciences

        2011-2013

        accommodation support, no funding for research activities

        In vitro maturation and fertilization of pig oocytes and cultivation of early embryos until blastocyst cleavage

        PI form IBIR, Professor D. Kacheva with the Instute of Animal Physiology and Genetics, Czech Republic

        2011-2013

        accommodation support, no funding for research activities

        Improvement of embryo transfer biotechnology in domestic animals.

        PI form IBIR, Professor D. Kacheva

        Egyptian Academy of Sciences

        2009-2012

        accommodation support, no funding for research activities

         

         

         

        20.1. National projects

        Projects financed by the Ministry of Education and Science

         

        Localization and function of stress proteins in testicular germ cells in heat-induced and spontaneous apoptosis.

        Associate Professor Dr. Margarita Mollova

        2007-2010

        25000 lv

        New temperature-sensitive superoxide dismutase from Antarctic fungi: biotechnological study, chemical characterization and application”. Associate Professor Dr. Margarita Mollova

        2010-2012

        19530 lv

         

        The Importance of calcium-binding protein Secretagogin in hormone-secreting neuroendocrine cells.

        Assistant Professor Teodora Daneva

        2007-2010

        20600 lv

        Building Scientific Research Centre on the problems in reproductive health" under Program "Development of scientific infrastructure”. Associate Professor Dr. Margarita Mollova

        2008-2012

        800 000 lv

        Isolation and Characterization of Human Skin Stem Cells: a search for new targets for the therapy of skin cancer.

        Prof. I. Kehayov

        2008-2012

        250 000 lv

        Investigation on the plasticity of human mesenchymal stem cells.

        Prof. S. Kyurkchiev

        2007-2010

         

        29 200 lv

        Investigation on the possibilities for control of proliferation of tumor cells through specific siRNA mollecules.

        Prof. I. Kehayov

        2007-2010

         

        25 000 lv

        Investigation on antioxidant potential of melatonin for improving the reproductive capacity in idiopathic male infertility and varicocele.

        Assoc. Prof. R. Konakchieva

        2008-2010

         

        20 000 lv

        Comparative studies on methods for isolation, culturing, differentiation and cryopreservation of hematopoietic stem cells from umbilical blood.

        Assoc. Prof. P. Todorov

        2009-2012

         

        100 000 lv

        Investigation of approaches for higher effect of buffalo reproduction.

        Assoc. Prof. M. Ivanova-Kicheva, Prof. D. Kacheva

        2007-2011

         

        25 000 lv

        Co-financing project to the ReProForce FP-7- REGPOT-2009-1 reinforcement of the research capacity of the bulgarian institute “biology and immunology of reproduction”.

        Project Coordinator Prof. M. Mollova

        2009-2013

         

        324 030 lv

        Gene regulatory networks based on siRNA, transcription factors and fusion oncoproteins in prostate cancerogenesis and their application in diagnostics and therapeutics

        Assistant Professor Dr Krassimira Todorova-Hayrabedyan

        2011-2013

        44976 lv

        Ananlysis of rare Bulgarian sheep breeds – preservation and sustained utilisation

        Assist. Prof. Aleksander Kukov

        2011-2013

        46445 lv

        “Manual on reproduction in domestic animals and reproductive biotechnologies”

        Assoc. Prof. M. Sabev

         

        2011-2012

         

        4956 lv

        Izolation, characterization and in vitro differentiation of ovarian stem cells

        Assoc. Prof. P.Todorov

         

        2012-

         

        150 000 lv

         

         

         

        Projects financed by Bulgarian Academy of Sciences (salary only) 2010-2012

         

        Total financial input for salary 2010-2012 -   700529 lv/ 358174 euro

         

        Title

        Duration

        Development of xeno-free conditions for culturing of human embryonic stem cells (line BG01V).

        Assoc. Prof. Tsvetelina Oreshkova

        2010-2012

        Development of laboratory protocols for derivation of induced pluripotent stem cells.

        Assoc. Prof. Milena Mourdjeva

         

        2010-2012

        Influence of the biological active substances on the female reproductive potential and embryo development.

        Assoc. Prof. Е.Kistanova

         

        2007-2012

        Morphological characteristic of sperm and spermatozoid-specific proteins and enzymes, related to fertilizing ability.

        Assoc. Prof. B.Georgiev

         

        2007-2012

        Immuno-endocrine regulation of luteinisation and apoptosis in preovulatory folicle.

        Assistant Professor Ivaylo Vangelov, Assistant Professor Julieta Dineva

         

        2010-2012

        Non-invasive test of the genetic potential of cumulus cells as biomarkers for selecting oocytes in program for in vitro fertilization.

        Assistant Professor Dr Krassimira Todorova-Hayrabedyan

         

        2010-2012

        Pregnancy and Diabetes.

        Dr Katya Todorova, Ph.D. and assistant Kameliya Petkova

         

        2008-2010

        Studies over cytotoxicity on PC3 cell line of porfirin compounds.

        Assistant Professor Diana Zasheva

         

        2010-2012

        Influence of antiphospholipids antibody on reproductive cells.

        Assistant Professor K. Uzunova

         

        2008-2010

        Investigation of viability of Ovis aries spermatozoa after seminal plasma separation.

        Assoc. Prof. M. Sabev

         

         

         2008-2010

        Studying the effect of different protectors and biotechnologies for storage of mammal’s spermatozoa at low temperatures.

        Assoc. Prof. M Ivanova-Kicheva and Assistant K. Lazov

         

        2008-2010

        Investigation of sheep fertility after artificial insemination with semen stored at low temperatures.

        Assistant Prof. R. Stefanov

         

        2008-2010

        Characterization of the protective role of seminal plasma proteins on the biological characteristics and adaptation capabilities of ram spermatozoa stored at low temperatures.

        Assoc. Prof. M Ivanova-Kicheva

         

        2010-2012

        Investigation of the role of metaloproteinases in mamary gland development in dogs

        Associate Professor Pavel Rashev

         

        2011-2012

        SCGN as probable tumor supressive gene 

        Assistant Professor Teodora Daneva

         

        2011-2012

        Investigation of relation between sensor signals and reproductive processes in normal and pathological conditions

        Prof. S. Lolov

         

        2011-2012

        Influence of egg yolk lipoproteins on boar spermatosoids in low temperature

        Assoc. Prof. M Ivanova-Kicheva

         

        2009-2011

        Strutural analysis of small proteins isolated from ram seminal plasma

        Assoc. Prof. M Ivanova-Kicheva

         

        2011-2012

        Investigation of oxidative-antioxidative status, qualitative parameters of spermatozoa and some biochemical characteristics in boar seminal fluid.

        Assistant Prof. R. Stefanov

         

        2011-2012

        Damage on untracellular proteins as a result of toxic effect of free radicals in cryopreserved ram sperm

        Assistant Prof. R. Stefanov A

         

         2011-2012

        Role of neuroendocrine factors in ethiology of methabolic and endocrine resistence

        Ass. Prof Georgi Georgiev

         

        2011-2012

        Investigation of melatonon action in seminal fluid in healthy men and patients with idiopatic infertility

        Assoc. Prof. R. Konakchieva

         

        2011-2012

        Sanitary aspects of embriobiotechnology in animals

        Prof. D. Kacheva

         

        2010-2012

        Optimization of biotechnology for cryoconservation of bufalo sperm

        Assoc. Prof. M Ivanova-Kicheva

         

        2012-

        Involvement of metalloproteinases in spermatogenesis and fertilization in humans

        Associate Professor Pavel Rashev

         

        2012-

        Studies on mucous immunity and the immune response

        Prof. S. Lolov

        2012-

        Staged specific expression of a DNA helicase RUVBL1/TIP49a during spermatogenesis

        Assistant Professor Teodora Daneva

        2012-

        Molecular interactions between human mesenchymal stem cells and tumors - a model to search for new antitumor agents

        Medical University, Sofia – prof. I.Altynkova; IBIR team is presented by Assoc. Prof. Milena Mourdjeva

         

        2011-

        Expression of immunoregulatory markers in in vitro decidualization of human stromal cells isolated from a parietal deciduas

        Assoc. Prof. Tsvetelina Oreshkova

         

        2012-

        Biochemical characterization of endometriosis peritoneal fluid

        Assoc. Prof. Maria Stamenova

         

        2012-

        System for regulation of the output of mitosis and its importance for the development of prostate cancer

        Assistant Professor Diana Zasheva

         

        2012-

        Optimization of systems of selection and reproduction in sheep from SPBM for efficient production. Analysis and evaluation of genealogical structure

        Prof. D. Kacheva for IBIR and Prof. E. Raycheva for Kostinbrod

         

        2012-

        Validation of the biological effects of H. rhodopensis to genotoxic and oxidative stress and activation of innate immunity

        Assistant Professor Dr SorenHayrabedyan

         

        2012-

         

        Projects with additional financing fromGovernmental institutions and Bulgarian companies 

        Project "Impact of anti-ovarian antibodies on fertility”.

        Assistant Professor Julieta Dineva , Assistant Prof. Ivaylo Vangelov

         

         

        2010-2012

         

        300 lv

        Supporting the practice of AI of sheep

        Assoc. Prof. M. Sabev, two participants

        2010-2012

        150 lv

         

        Cooperative program for research and development with Obst.

         Gyn. Center “Dimitrov”

        Res. Assoc. P. Todorov

         

        2010-2012

         

        consumables only

        The role of metalloproteinases in pathogenesis of breast cancer and their significance as prognostic markers for early diagnosis of disease.

        Assistant Prof. Rumen Kirilov Dimitrov

         

        2010

        consumables only

        Development of modern biotechnology in the cryopreservation of semen from different livestock species.

        Assoc. Prof. M. Ivanova-Kicheva,

         

        2010-2012

         

        11000 lv

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