Main research topics

Head of department - Assoc. prof. Pavel Istiliynov Rashev

Basic research topics

• Factors and mechanisms controlling cell proliferation, differentiation and apoptosis in male and female reproductive systems.
• Identification, characterization and functional activity of receptors and ligand molecules participating in gametes interaction.
• Immune-endocrine regulation of the ovarian function. Biological and clinical significance of autoimmunity against ovarian antigens.
• Local regulatory factors and mechanisms in structural remodeling of cellular immunity during the phases of implantation and pregnancy.
• Development of model systems and methods for the study of the fertilizing capability of gametes in vitro, the diagnosis and treatment of immunologically mediated infertility in humans and animals. 
• Role of metalloproteinases in normal breast physiology and in breast pathology.