• Institute of Biology and Immunology of Reproduction
      "Acad. Kiril Bratanov"

      • Scientific publications

        Full list of research papers could be found at staff ResearchGate profies here:

        Assoc. Prof. Krassimira Todorova, DSc ,

        Assof. Prof.Soren Hayrabedyan, MD, PhD ,

        Assoc. Prof. Diana Zasheva .



        1. Soren Hayrabedyan, Krassimira Todorova. Method and kit for detection of cancer fusion protein. Filled National Patent Office 2014. Currently pending.


        Book Chapters

        1. K. Todorova, S. Hayrabedyan: The stem cell paradigm and its application to prostate cancer- an old and yet still young idea. Handbook of Prostate Cancer Cell Research: Growth, Signalling and Survival, Edited by Alan T. Meridith, 01/2009: chapter The stem cell paradigm and its application to prostate cancer- an old and yet still young idea: pages 127-176; Nova Science Publishers., ISBN: 978-1-61728-435-9

        Journal Publications

        1. Soren Hayrabedyan, Krassimira Todorova, Asma Jabeen, Gergana Metodieva, Stavri Toshkov, Metodi V Metodiev, Milcho Mincheff, Nelson Fernández: Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production. Scientific Reports 02/2016; 6(18896):1-17. DOI:10.1038/srep18896
        2. Yung Chih Chen, Jennifer Rivera, Melissa Fitzgerald, Christian Hausding, Ya-Lan Ying, Xiaowei Wang, Krassimira Todorova, Soren Hayrabedyan, Eytan R Barnea, Karlheinz Peter: PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids. Thrombosis and Haemostasis 02/2016; 115(5). DOI:10.1160/TH15-08-0640
        3. Eytan R. Barnea, Soren Hayrabedyan, Krassimira Todorova, Osnat Almogi-Hazan, Reuven Or, Joy Guingab, James McElhinney, Nelson Fernandez, Timothy Barder: PreImplantation factor (PIF*) regulates systemic immunity and targets protective regulatory and cytoskeleton proteins. Immunobiology 02/2016;  DOI:10.1016/j.imbio.2016.02.004
        4. Soren B Hayrabedyan, Diana Y Zasheva, Krassimira O Todorova: NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells. Folia medica 10/2015; 57(1):43-48. DOI:10.1515/folmed-2015-0018
        5. Krassimira Todorova, soren hayrabedyan: Mir-15A Reconstitution in Prostate Cancer Cell Line Suppresses Cancer Progression Through Down Regulation of MYB and Androgen Receptor Upregulation. Acta Medica Bulgarica 05/2015; 42(1):18-22. DOI:10.1515/amb-2015-0003
        6. Soren Hayrabedyan, Krassimira Todorova: Nalp Signalling is Required in Sertoli Cells for Tight-Junction Protein Interaction. Acta Medica Bulgarica 05/2015; 42(1):12-17. DOI:10.1515/amb-2015-0002
        7. Eytan R. Barnea, David Kirk, Krassimira Todorova, James McElhinney, Soren Hayrabedyan, Nelson Fernández: PIF Direct Immune Regulation: Blocks Mitogen-Activated PBMCs Proliferation, Promotes TH2/TH1 Bias, independent of Ca2+. Immunobiology 01/2015; 220(7). DOI:10.1016/j.imbio.2015.01.010
        8. Krassimira Todorova, Metodi V Metodiev, Gergana Metodieva, Diana Zasheva, Milcho Mincheff, Soren Hayrabedyan: miR-204 is Dysregulated in Metastatic Prostate Cancer In Vitro. Molecular Carcinogenesis 01/2015; 55(2). DOI:10.1002/mc.22263
        9. E.R. Barnea, D.M. Lubman, Y.-H. Liu, V. Absalon-Medina, S. Hayrabedyan: Erratum: Insight into PreImplantation Factor (PIF) mechanism for embryo protection and development: Target oxidative stress and protein misfolding (PDI and HSP) through essential RIPK binding site (PLoS ONE (2014) 9:7 (e100263) DOI:10.1371/journal.pone.0100263). PLoS ONE 11/2014; 9(11). DOI:10.1371/journal.pone.0113886
        10. Krassimira Todorova, Diana Zasheva, Kristiyan Kanev, Soren Hayrabedyan: miR-204 Shifts the Epithelial to Mesenchymal Transition in Concert with the Transcription Factors RUNX2, ETS1, and cMYB in Prostate Cancer Cell Line Model. 10/2014; 2014(840906). DOI:10.1155/2014/840906
        11. Eytan R Barnea, David M Lubman, Yan-Hui Liu, Victor Absalon-Medina, Soren Hayrabedyan, Krassimira Todorova, Robert O Gilbert, Joy Guingab, Timothy J Barder: Insight into PreImplantation Factor (PIF*) Mechanism for Embryo Protection and Development: Target Oxidative Stress and Protein Misfolding (PDI and HSP) through Essential RIPK Binding Site. PLoS ONE 07/2014; 9(7):e100263. DOI:10.1371/journal.pone.0100263
        12. K. Todorova, Diana Zasheva, Soren Hayrabedyan: Innate immunity challenge differently modulates inflammatory and apoptosis regulation in lymph node and bone marrow metastatic cell line models, favouring higher metastatic phenotype. Comptes rendus de l'Académie bulgare des sciences: sciences mathématiques et naturelles 01/2014; 67(11):1575-1582.
        13. Asma Jabeen, José Maria Miranda-Sayago, Boguslaw Obara, Patrick Simon Spencer, Gill Barbara Dealtry, Soren Hayrabedyan, Valerie Shaikly, Pierre Philippe Laissue, Nelson Fernández: Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. Biology of Reproduction 09/2013; 89(4). DOI:10.1095/biolreprod.113.111963
        14. Nelly Manolova, Soren Hayrabedyan, Krassimira Todorova, Diana Zasheva, Milena Mourjeva, Stanimir Kyurkchiev, Maria Stamenova: Endometriosis Peritoneal Fluid Factors Involved in the Alteration of Decidualization Process. 08/2013; 27(4-4):3982-3986. DOI:10.5504/BBEQ.2013.0032
        15. Soren Hayrabedyan, Krassimira Todorova, Diana Zasheva, Daniela Moyankova, Desislava Georgieva, Jordana Todorova, Dimitar Djilianov: Haberlea rhodopensis has potential as a new drug source based on its broad biological modalities. 02/2013; 27(1-1):3553-3560. DOI:10.5504/BBEQ.2012.0112
        16. Nelly Manolova, Soren Hayrabedyan, Krassimira Todorova, Diana Zasheva, Milena Mourjeva, Stanimir Kyurkchiev, Maria Stamenova: In search of factors in endometriosis peritoneal fluid that decreased decidualization process. 01/2013; 66(1-1):153-158. DOI:10.7546/CR-2013-66-1-13101331-20
        17. Soren Hayrabedyan, Milcho Mincheff, Diana Zasheva, Nelly Manolova, Krassimira Todorova: Autophagy Signalling is Differentially Modulated by miR-204 in Context of Innate Immunity Induction. 01/2013; 66(1-1):127-132. DOI:10.7546/CR-2013-66-1-13101331-16
        18. Krassimira Todorova, Milcho Mincheff, Soren Hayrabedyan, Jana Mincheva, Diana Zasheva, Aleksandar Kuzmanov, Nelson Fernández: Fundamental Role of microRNAs in Androgen-Dependent Male Reproductive Biology and Prostate Cancerogenesis. American Journal Of Reproductive Immunology 04/2012; 69(2). DOI:10.1111/j.1600-0897.2012.01139.x
        19. Patrick S Spencer, Soukaina M Hakam, Phillipe P Laissue, Asma Jabeen, Pallavi Jain, Soren Hayrabedyan, Krassimira Todorova, Alyssa Blanch, James M.W.R. McElhinney, Niwedhie Muhandiram, Shaza Alkhatib, Gill B Dealtry, Jose M Miranda-Sayago, Nelson Fernández: Key Cellular Components and Interactive Histocompatibility Molecules Regulating Tolerance to the Fetal Allograft. American Journal Of Reproductive Immunology 04/2012; 68(2):95-9. DOI:10.1111/j.1600-0897.2012.01138.x
        20. Soren Hayrabedyan, Krassimira Todorova, Shina Pashova, Margarita Mollova, Nelson Fernández: Sertoli Cell Quiescence – New Insights. American Journal Of Reproductive Immunology 04/2012; 68(6). DOI:10.1111/j.1600-0897.2012.01137.x
        21. Stanimir Kyurkchiev, Fulvio Gandolfi, Soren Hayrabedyan, Tiziana A L Brevini, Roumen Dimitrov, Justine S Fitzgerald, Asma Jabeen, Milena Mourdjeva, Stella M Photini, Patrick Spencer, Nelson Fernández, Udo R Markert: Stem Cells in the Reproductive System. American Journal Of Reproductive Immunology 04/2012; 67(6):445-62. DOI:10.1111/j.1600-0897.2012.01140.x
        22. K. Todorova, S. Hayrabedyan, J. Dineva, I. Vangelov, M. Ivanova, M. Mollova: Gene panel in human cumulus cells as a biomarker for successful in vitro procedures (vol 64, pg 1143, 2011). 03/2012; 93(2-2):123. DOI:10.1016/j.jri.2012.02.001
        23. K. Todorova, S. Hayrabedyan, J. Dineva, I. Vangelov, D. Zasheva, V. Penchev, G. Nikolov, M. Mollova, M. Ivanova: Cumulus biomarker evaluation for human oocyte quality prediction. Acta Medica Bulgarica 01/2012; 39(1):70-76.
        24. K. Todorova, N. Manolova, D. Zasheva, S. Hayrabedyan: A relationship between microRNA204 and occludin in prostate cancer inflammation signaling. Acta Medica Bulgarica 01/2012; 39(2-2):23-28.
        25. Krasimira Todorova, Milcho Mincheff, Diana Zasheva, Soren Hayrabedyan: The role of miR-204 and nod1 receptor in prostate cancer inflammation signalling. 01/2012; 65(12-12):1739-1744.
        26. Soren Hayrabedyan, Boyko Georgiev, Dimitrina Kacheva, Mihail Chervenkov, Kiril Shumkov, Paulina Taushanova, Elena Kistanova: Flowcytometry as a method for advanced evaluation of boar semen. 01/2012; 65(4-4):541-548.
        27. Boyko Georgiev, Soren Hayrabedyan, Krassimira Todorova, Diana Zasheva, Paulina Taushanova, Dimitrina Kacheva, Peter J. Hansen: Sperm proteins as potential markers of boar fertility. 01/2012; 65(4-4):533-540.
        28. Krassimira Todorova, Diana Zasheva, Soren Hayrabedyan, Julieta Dineva, Ivailo Vangelov, Valentin Penchev, Georgi Nikolov, Margarita Mollova, Maria Ivanova: Gene panel in human cumulus cells as biomarker for successful in vitro procedures. 01/2011; 64(8-8):1143-1150.
        29. K. Todorova, I. Georgiev, J. Dineva, V. Penchev, S. Hajrabedyan, G. Nikolov, M. Molova, M. Ivanova: Lysil oxidase as a potential biomarker for predicting oocyte quality.
        30. V S Sarafian, Y Uzunova, S Hayrabedyan, P Ganchevska, M Filipova, I Filipov, L Lukanov, S Vladimirov: Histo-blood group antigen expression and proliferative activity of fibroblasts treated with dental monomers. Cell Biology and Toxicology 02/2008; 24(1):27-37. DOI:10.1007/s10565-007-9013-2
        31. Milen Karaivanov, Krasimira Todorova, Soren Hayrabedyan: Immunohistochemical quantitative assesment of the expression of GSTP1, iNOS and COX-2 in PIA, PIN and carcinoma in the prostate gland. 01/2008; 452:S186.
        32. Soren Hayrabedyan, Stanimir Kyurkchiev, Ivan Kehayov: Calcium-binding protein S100A13 is overexpressed in endometriosis. 01/2008; 61(2-2):281-288.
        33. Dobroslav Kyurkchiev, Ekaterina Ivanova-Todorova, Soren Hayrabedyan, Iskra Altankova, Stanimir Kyurkchiev: Female Sex Steroid Hormones Modify Some Regulatory Properties of Monocyte‐Derived Dendritic Cells. American journal of reproductive immunology (New York, N.Y.: 1989) 12/2007; 58(5):425-33. DOI:10.1111/j.1600-0897.2007.00526.x
        34. M Karaivanov, K Todorova, A Kuzmanov, S Hayrabedyan: Quantitative immunohistochemical detection of the molecular expression patterns in proliferative inflammatory atrophy. Journal of Molecular Histology 04/2007; 38(1):1-11. DOI:10.1007/s10735-006-9070-5
        35. Aleksandar Kuzmanov, Soren Hayrabedyan, Milen Karaivanov, Krassimira Todorova: Basal cell subpopulation as putative human prostate carcinoma stem cells. Folia Histochemica et Cytobiologica 02/2007; 45(2):75-80.
        36. K. Todorova, T. Shamov, S. Hayrabedyan, A. Kuzmanov, S. Kyurkchiev, I. Kehayov: Quantitative evaluation of angiogenesis in globlastoma with CD105. 01/2007; 60(5-5):575-578.
        37. Krassimira Todorova, Soren Hayrabedyan, Todor Shamov, Milen Karaivanov, Alexandar Kuzmanov, Stanimir Kyurkchiev, Ivan Kehayov: Quantitative evaluation of AMACR in gliobastoma. 01/2007; 60(10-10):1123-1126.
        38. K. Todorova, S. Hayrabedyan, I. Kehayov, S. Kyurkchiev: Quantitive assessment of the expression levels of PSMA, hCG and endoglin in prostate carcinoma tissues. Clinical Application of Immunology 10/2006; 5(1-1):543-547.
        39. M. Karaivanov, K. Todorova, A. Kuzmanov, S. Hayrabedyan, I. Kehayov, S. Kyurkchiev: Immunohistochemical comparative analysis of the expression of p63, amacr, COX-2 and GSTP1 in proliferative inflammatory atrophy, prostate intraepithelial neoplasia and prostate carcinoma. Differential diagnosis and predicative significance. 01/2006; 59(8):885-890.
        40. S. Hayrabedyan, S. Kyurkchiev, I. Kehayov: Evaluation of IL-1 alpha expression in endometriotic lesions using quantitative immunohistochemistry approach. 01/2006; 59(2):229-234.
        41. Soren Hayrabedyan, Stanimir Kyurkchiev, Ivan Kehayov: FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis. Journal of Reproductive Immunology 11/2005; 67(1-2):87-101. DOI:10.1016/j.jri.2005.07.001


    Custom Search
    Персонализирано търсене