• Institute of Biology and Immunology of Reproduction
      "Acad. Kiril Bratanov"

      • Publications

        Scientific papers published during last 5 years.


        Papers in International peer-reviewed scientific journals

        I.Ilieva, P.Tzvetkova, I.Sainova, P.Taushanova, M.Kacarov, E.Zvetkova    Immature spermatogenic cells in semen fluids of infertile men. Compt.Rend.Acad.Bulg.Sci., 69, 1, 85-94, 2016.
        ISSN: 1310-1331    IF: 0.284

        S.Manchev, R.Stefanov, G.Anev, P.Cvetkova, N.Maksimovic Effect of melatonin on the reproductive characteristics of rams of north east Bulgarian fine fleece breed. Compt.Rend.Acad.Bulg.Sci., 67, 12, 1701-1706, 2014.
        ISSN: 1310-1331 IF: 0.284

        P.D.Cvetkova, I.N.Ilieva Polyorchidism and fertility. MD-Medical Data, 6, 1, 29-32, 2014.
        ISSN: 1821-1585

        P.Tzvetkova, I.Ilieva, S.Rangelov, I.Babyuk, S.Shamraev Changes in the secretion of gonadothropins LH, FSH and infertility. Compt.Rend.Acad.Bulg.Sci., 66, 3, 459-466, 2013.
        ISSN: 1310-1331         IF: 0.198

        I.Ilieva, S.Ivanova, S.Rangelov, P.Tzvetkova, V.Ormandzhieva, E.Petrova Sperm changes in cases with Varicocele. Compt.Rend.Acad.Bulg.Sci., 66, 5, 757-764, 2013.
        ISSN: 1310-1331 IF: 0.198

        E.Vachkova, B.Bivolarski, M.Gulubova, R.Konakchieva, I.P.Georgiev, R.Simeonov Immunohistochemical localization of EGF receptors in the intestinal tract of growing rabbits in relation to age. Livestock Science, V.142, 216-221, 2011.
        ISSN: 1871-1413;       IF - 1.506

        R.Konakchieva, P.Todorov Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways. Letter to Editor. Fertility and Sterility, V.96, No 4 e159, 2011.
        ISSN: 0015-0282;      IF - 3.958 

        Papers in National (Bulgarian) scientific journals

         П.Цветкова, П.Таушанова, С.Манчев FSH и фертилитет. Андрология, 24, 3, 10-12, 2015.
        ISSN: 1310-3806

        П.Цветкова, П.Таушанова, И.Костадинова, С.Манчев Тестостерон и мъжка репродуктивна патология. Уронет, 1, 9 – 16, 2015.
        ISSN:1312-1960

        P.Tzvetkova, I.Ilieva, M.Kacarov, E.Zvetkova, J.Chitalov, Iv.Dechev Immature spermatogenic cells in semen fluids of infertile men. Андрология, 24, 4, 2-5, 2015.
        ISSN: 1310-3806

        I.Ilieva, P.Tzvetkova, M.Kacarov, I.Sainova, P.Taushanova, I.Vladov, E.Zvetkova Round Immature Spermatogenetic Cells in Semen Fluids of Infertile Men with Diagnosis "Migrating Testis”. Two Casuistic Cases in Adults. Acta Morphologica et Anthropologica, 22, 15-23, 2015.
        ISSN: 0861-0509

        Ю.Караиванова Влияние на тежките метали върху репродукцията на организма. Андрология, 24, 4, 15-20, 2015.
        ISSN: 1310-3806

        И.Костадинова Микрочастици в мъжкия урогенитален тракт. Андрология, 24, 1, 12-14, 2015.
        ISSN: 1013-3806

        С.Манчев, П.Таушанова, И.Костадинова Физиологична роля ма мелатонина и инфертилитет. Андрология, 23, 2, 6-11, 2014.
        ISSN: 1013-3806

        П.Таушанова, Ю.Караиванова, П.Цветкова Биохимична характеристика на семенната плазма и нейното клинично значение. Андрология, 23, 2014, 4, 16-19.
        ISSN: 1310-3806

        П.Таушанова Глюкокортикоид – зависима модулация и мелатонин. Андрология, 23, 3, 17-19, 2014.
        ISSN: 1310-3806

        П.Таушанова Ефект на мелатонин в in vitro модели на антиген/митоген стимулирана пролиферация на клетъчни култури от човешки лимфоцити. Андрология, 23, 2014, 4, 7-10.
        ISSN: 1310-3806

        П.Таушанова Участие на епифизния хормон мелатонин в имунорегулацията. Андрология, 23, 3, 7-10, 2014.
        ISSN: 1310-3806

        И.Илиева, П.Цветкова Антиоксидантна защита на сперматозоидите при оксидативен стрес. Андрология, 23, 1, 14-20, 2014.
        ISSN: 1013-3806

        П.Цветкова Клинично значение на подвижността на сперматозоидите. Андрология, 23, 2, 16-18, 2014
        ISSN: 1013-3806

        П.Цветкова, Й.Узунова, С.Рангелов, И.Бабюк, С.Шамряев Морфологични нарушения в тестикуларната тъкан при прекъсната сперматогенеза ха ниво сперматиди. Урология, 20, 1, 22-27, 2014
        ISSN: 1310-6058

        И.Костадинова Експресия и физиологична роля на ароматаза в мъжки полови клетки. Андрология, 23, 3, 11-19, 2014.
        ISSN: 1310-3806

        Р.Конакчиева Имуноневроендокринология – приемственост и развитие. Списание на БАН, 127, 1, 27-30, 2014.
        ISSN: 0007-3989

        И.Илиева, П.Цветкова Влияние на оксидативния стрес върху сперматогенезата, спермазоидите и патология на мъжката гюлова система. Андрология, 22, 4, 12-20, 2013.
        ISSN: 1310-3806

        В.Георгиев, П.Цветкова Геномна активност при сперматогенезата. Андрология, 22,
        3,16-20,2013.
        ISSN: 1310-3806

        Рангелов С, П. Цветкова Кои са причините за мъжкия инфертилитет? Андрология, 22, 1,4-10,2013.
        ISSN: 1310-3806

        П.Цветкова, В.Георгиев Спермиацията - процес на освобождаване на зрели сперматиди в лумена на семенните каналчета. Андрология, 22, 2, 9-15, 2013.
        ISSN: 1310-3806

         

        Popular Science, Current Affairs publications and Educational publications
        Books and brochures
         

        1. Цветкова П. Медико-биологични аспекти на мъжкия инфертилитет и тяхното диагностично значение. Научна Фондация "Андрология", София, 2013, 258 с.
        ISBN: 987-954-92357-3-9

        G. Georgiev, J. Pastuschek, S. Neubeck, U. Markert Part I: Substances secreted by the preimplantation human embryo. Chapter 6 in Immunology of Pregnancy – 2013. ed. G. Chaouat, S. Olivier, N. Ledee; pp. 384-396, Bentham Science Publishers, 2013.
        ISBN: 978-1-60805-734-4, eISBN: 978-1-60805-733-7

         

        Previous publications

        Papers in National (Bulgarian) scientific journals

        1. Todorov P, Konakchieva R, Dimitrov J, Chub N, Petrenko Y. Vitrification of human embryonic stem cells for cryopreservation. Comptes rendus de l’Academie bulgare des Sciences 2005, 58, 9:1095-1100 ISSN: 1310-1331.

        2.Todorov P., Konakchieva R.,Dimitrov J. Effect of recombinant FSH on the synthesis and secretion of estradiol 17-beta from human granulosa cells in-vitro. Endocrinologia, 2005, X, 3:149-153 ISSN 1310-8131 .

        3. Todorov P., Konakchieva R., Dimitrov J., Slavchev B., Novachkov W. Cryopreservation of human ovarian tissue-our experience. Embryologia 2006, 1: 4-8 ISSN 1312-7349.

        4. Автански Д. Действие на тиазолидиндиони върху стероидогенезата в човешки яйчник: ин витро изследване. Ендокринология 2006; XI, 3:170-177 ISSN 1310-8131.

        5.Georgiev G., Konakchieva R. Epigenetic modeling of the embryonal and the postnatal development. Embryologia. 2007, 2, 1:16-20 ISSN 1312-7349.

        6.Gjorgovska N, Filev K, Konakchieva R. Influence of induced molting on hormonal status of aged laying hens. Krmiva (Zagreb) 2008; 1; 19-25 ISSN: 0023-4850.

        Papers in International peer-reviewed scientific journals

        7. Seto-Young D, Paliou M, Schlosser J, Avtanski D, Park A, Patel P, Holcomb K, Chang P, Poretsky L Direct thiazolidine action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 production. J Clin Endocrinol Metab 90(11):6099-6105, 2005 ISSN: 0021-972X (IF=5.8).

        8.Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L.Interactions among peroxisome proliferator activated receptor-γ, insulin signaling pathways and steroidogenic acute regulatory protein in human ovarian cells.J Clin Endocrinol Metab 92(6):2232-9, 2007 ISSN: 0021-972X (IF=5.8).

        9. Таushanova P., Georgiev G, Manchev S, Konakchieva R. Effect of glucocorticoids on melatonin receptor expression under T-cell activated immune response. Comptes Rendus de l, Academie des Sciences, 60:899-902, 2007 ISSN: 1310-1331 (IF=0.106).

        10. Stephanova E., Topouzova-Hristova T., Konakchieva R. Mitochondria are involved in stress response of A549 alveolar cells to halothane toxicity.Toxicology In Vitro; 22(3):688-694, 2008 ISSN 0887-2333 (IF=2.05).

        11. Tomova A., Kumanov P., Robeva R., Manchev S., Konakchieva R. Melatonin secretion and non-specific immune responses are differentially expressed in corticotropin-dependent and corticotropin-independent Cushing’s syndrome. Medical Science Monitor; 14(6):CR327-332, 2008 ISSN (electronic) 1643-3750 (IF= 1.59).

        12. Todorov P., Hristova E., Konakchieva R., Michova A., Dimitrov Y. Comparative studies of different cryopreservation methods for mesenchymal stem cells derived from human fetal liver. Cell Biology International; 34:455-462, 2010.ISSN 1065-6995 (IF=1.62)

        13. Vachkova E, Penchev I, Georgiev B, Biviloarski B, Konakchieva R. Relationships between plasma concentrations of Epidermal Growth Factor,            insulin and iodated thyroid hormones in early andnormal weaned rabbits. Revue Méd. Vét. 161, 1, 30-36, 2010 ISSN: 0035-1555 (IF=0.09).

        14.Todorov P., Konakchieva R, Dimitrov Y., Novachkov V., Kyurkchiev D., Tchoob N., Gorohova N. Morphological and functional assessment of             human fetal     liver cells in long-term culture. Problems of Cryobiology 2006, 2: 201-206 ISSN: 0233-7673.

        15.Dineva J., Vangelov I., Nikolov G., Konakchieva R., Ivanova M. Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone byhuman granulose luteinized cells with an antiapoptotic effect. Endocrine Regulations; 42 (2-3):45-51, 2008 ISSN (electronic): 1336-0329.

         

        1. Seto-Young D, Paliou M, Schlosser J, Avtanski D, Park A, Patel P, Holcomb K, Chang P, Poretsky L Direct thiazolidine action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 production. J Clin Endocrinol Metab 90(11):6099-6105, 2005 (IF=5.8).
        2. Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L. Interactions among peroxisome proliferator activated receptor-γ, insulin signaling pathways and steroidogenic acute regulatory protein in human ovarian cells. J Clin Endocrinol Metab 92(6):2232-9, 2007 (IF=5.8).
        3. Таushanova P., Georgiev G, Manchev S, Konakchieva R. Effect of glucocorticoids on melatonin receptor expression under T-cell activated immune response. Comptes Rendus de l, Academie des Sciences, 60:899-902, 2007 (IF=0.106).
        4. Stephanova E., Topouzova-Hristova T., Konakchieva R. Mitochondria are involved in stress response of A549 alveolar cells to halothane toxicity. Toxicology In Vitro; 22(3):688-694, 2008 (IF=2.05).
        5. Tomova A., Kumanov P., Robeva R., Manchev S., Konakchieva R. Melatonin secretion and non-specific immune responses are differentially expressed in corticotropin-dependent and corticotropin-independent Cushing’s syndrome. Medical Science Monitor; 14(6):CR327-332, 2008 (IF= 1.59).
        6. Todorov P., Hristova E., Konakchieva R., Michova A., Dimitrov Y. Comparative studies of different cryopreservation methods for mesenchymal stem cells derived from human fetal liver. Cell Biology International; 34:455-462, 2010 (IF=1.62)
        7. Vachkova E, Penchev I, Georgiev B, Biviloarski B, Konakchieva R. Relationships between plasma concentrations of Epidermal Growth Factor,     insulin and iodated thyroid hormones in early andnormal weaned rabbits.     Revue Méd. Vét. 161, 1, 30-36, 2010 (IF=0.09).
        8. Todorov P., Konakchieva R, Dimitrov Y., Novachkov V., Kyurkchiev D., Tchoob N., Gorohova N. Morphological and functional assessment of     human fetal     liver cells in long-term culture. Problems of Cryobiology 2006, 2: 201-206.
        9. Dineva J., Vangelov I., Nikolov G., Konakchieva R., Ivanova M. Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone byhuman granulose luteinized cells with an antiapoptotic effect. Endocrine Regulations; 42 (2-3):45-51, 2008.
        10. Seto-Young D, Avtanski D, Parikh G, Suwandhi P, Strizhevsky M, Araki T, Rosenwaks Z, Poretsky L. Rosiglitazone and pioglitazone inhibit estrogen synthesis in human granulosa cells by interfering with androgen binding to aromatase. Horm Metab Res 43:1-8, 2011 [article in press]

        Publications in national journals without IF
        1. Todorov P, Konakchieva R, Dimitrov J, Chub N, Petrenko Y. Vitrification of human embryonic stem cells for cryopreservation. Comptes rendus de l’Academie bulgare des Sciences 2005, 58, 9:1095-1100.
        2. Todorov P., Konakchieva R., Dimitrov J. Effect of recombinant FSH on the synthesis and secretion of estradiol 17-beta from human granulosa cells in-vitro. Endocrinologia, 2005, X, 3:149-153.
        3. Todorov P., Konakchieva R., Dimitrov J., Slavchev B., Novachkov W. Cryopreservation of human ovarian tissue–our experience. Embryologia 2006, 1: 4-8.
        4. Автански Д. Действие на тиазолидиндиони върху стероидогенезата в човешки яйчник: ин витро изследване. Ендокринология 2006; XI, 3:170-177
        5. Georgiev G., Konakchieva R. Epigenetic modeling of the embryonal and the postnatal development. Embryologia. 2007, 2, 1:16-20.
        6. Gjorgovska N, Filev K, Konakchieva R. Influence of induced molting on hormonal status of aged laying hens. Krmiva (Zagreb) 2008; 1; 19-25.

        PARTICIPATION IN SYMPOSIA
        1. Seto-Young D, Paliou M, Schlosser J, Patel P, Park A, Avtanski D, Latif W, Babar N, Yeshou D, Omry G, Holcomb K, Poretsky L Peroxysome     proliferator-activated receptor g (PPARg) in human ovarian cells: its role in regulation of steroidogenesis and IGFBP-1 production The Endocrine Society’s 87th AnnualMeeting, San Diego, CA, USA, Abstract P3-564 , 2005.
        2. Dineva J., Vangelov I., Konakchieva R., Stefanova Ts., Ivanova M. „ Studies on the immunoendocrine regulation of cell survival and apoptosis in preovulatory human follicle”, 5th European Congress of Reprod Immunol., Aug.-Sep. 2007.
        3. Dineva J., Vangelov I, G. Nikolov, R. Konakchieva, Ts. Stefanova, M. Ivanova Study on the survival role of ANP-cGMP-P and NO in human periovulatory follicle. X International congress of reproductive immunology, Opatija, Croatia,     June 10-14, 2007.
        4. Konakchieva R, Manchev S, Tomova A, Kumanov P. Neuroendocrine and immune correlates of impaired hypothalamo-pituitary-adrenal function. Exp Clin Endocrinol Diabetes 2005 9th Annual Meeting Deutsche Neuroendokrinologie Group, Dresden Germany.
        5. Динева Ж., Вангелов И., Конакчиева Р, Николов Г, Иванова М, „Апоптоза на гранулоза лутеинни (GLCs) и кумулусни клетки (CCs) свързана с възрастта на жени в програма за IVF”. Шести Национален Конгрес по Стерилитет, Контрацепция и Хормонозаместителна терапия, Боровец, 13-16 Март 2005
        6. Аvtanski D., D. Seto-Young, R. Konakchieva, L. Poretsky Insulin- independent and insulin-sensitizing effects of thiazolidinediones in human ovary. 11th Int. Symp. of Immunology of Reproduction, Varna, 2-4 June 2006.
        7. Dineva J., I. Vangelov, G. Nikolov, R. Konakchieva, J. Martinova, M. Ivanova In vitro study on the role of epidermal growth factor, progesterone and cyclc guonosine monophosphate on granuslose cells survival. 11th Int. Symp. of Immunology of Reproduction, Varna, 2-4 June 2006.
        8. J. Dineva, I. Vangelov, G. Nikolov, R. Konakchieva, M. Ivanova Comparative studies of some parametters for success in patients treated with GnRHa (Decapeptyl) and GnRHant (Orgalutran) from assisted reproduction program. 8th National Congress of Infertility, Contraception and Hormone-replacement therapy and Gynaecological Endoscopy with international participation, Borovetz, 17-19 of March 2007.
        9. J. Dineva, I. Vangelov, G. Nikolov, R. Konakchieva, Ts. Stefanova, M. Ivanova Study on the survival role of ANP-cGMP-P and NO in human periovulatory follicle. X International congress of reproductive immunology, Opatija, Croatia, June 10-14, 2007; American Journal of Reproductive Immunology 57 (2007), 379-481, ICRI 07-1-31
        10. J. Dineva, I. Vangelov, R. Konakchieva, Ts. Stefanova, M. Ivanova Studies on the immunoendocrine regulation of cell survival and apoptosis in preovulatory human follice. XIIIth Symposium of Czech reproductive immunologists with international participation, Zdar nad Sazavou, 24-27 May, 2007. American Journal of Reproductive Immunology 58 (2007), 181-237, SOP 19
        11. I. Wawrek, R. Konakchieva. 3rd EMBIC Summer School, Jena, Germany 2007. POS 39.
        12. J.Dineva, I.Vangelov, R.Konakchieva, Ts.Stefanova, M.Ivanova, “Studies on the local immunoendocrine regulation of cell survival in preovulatory human follicle” V European congress of Reproductive immunology, Berlin, 3-7 september, 2007 Journal of Reproductive Immunology 81 (2009), pp.152
        13. V. Ivanova, I. Wawrek, R. Konakchieva Influence of endocrine and paracrine factors on the functional characteristics of spermatozoa of men with idiopathic infertility. 9th National Congress of Infertility, Contraception, HRP and Gynaecological Endoscopy with International Participation, 11-14 April, 2008.
        14. G. Georgiev, I. Wawrek, R. Konakchieva Effects of growth factor and glucocorticoids on the steroidogenic response of human granulose cells in vitro. 9th National Congress of Infertility, Contraception, HRP and Gynaecological Endoscopy with International Participation, 11-14 April, 2008.
        15. Dineva J, Vangelov I, Nikolov G, Gulenova D, R. Konakchieva     Stefanova Tz, Ivanova M. The atrial natriuretic peptide- cGMP- progesterone     and nitric oxide as a pro- survival factors for human granulosa luteinized cells. 12th International Symposium of Immunology of Reproduction, ISIR June 25- 27, Varna, Bulgaria, 2009
        16. MD Ivanova, J. Dineva, I. Vangelov, R. Konakchieva, V. Terzieva. Studies on the local immunoendocrine regulation of cell survival in preovulatory human follicle. 7th European Congress on Reproductive Immunology. September 17-20, 2009 Marathon, Greece.
        17. MD Ivanova, J. Dineva, I. Vangelov, R. Konakchieva, V. Terzieva. Studies on the local immunoendocrine regulation of cell survival in preovulatory human follicle. 12th International Symposium of Immunology of Reproduction, ISIR June 25- 27, Varna, Bulgaria, 2009    
        18. Avtanski D, Strizhevsky M, Parikh G, Araki T, Rosen O, Demetri C, Goldman M, Cadag S, Rosenwaks Z, Poretsky L, Seto-Young DThe effects of thiazolidinediones on estrogen production in human granulosa cells The Endocrine Society’s 89th Annual Meeting, Toronto, Canada, Abstract P1-317, 2007
        19. Avtanski D, Park A, Kaplun J, Strizhevsky M, Kantor Y, Holcomb K, Poretsky L, Seto-Young DEffects of mitogen-activated protein kinase (MAPK) inhibition on progesterone and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells The Endocrine Society’s 88th Annual Meeting, Boston, MA, USA, Abstract P1-409, 2006
        20. Avtanski D, Kaplun J, Strizhevsky M, Park A, Patel P, Kantor Y, Kearny Brown M, Dhillon S, Pang X, Goldman M, Yeshou D, Moosavy A, Holcomb K, Rosenwaks Z, Seto-Young D, Poretsky L Interactions among PPARg, insulin signaling pathways and aromatase in human ovarian cells The Endocrine Society’s 88th Annual Meeting, Boston, MA, USA, 2006 Abstract P1-397.
        21. Seto-Young D, Avtanski D, Poretsky L Insulin, peroxisome proliferator-activated receptor γ signaling in human ovary – basic mechanisms and clinical implications 11th International Symposium of Immunology of Reproduction, Varna, Bulgaria, 2006
        22. Avtanski D, Seto-Young D, Parikh G, Strizhevsky M, Feng Y, Pareek A, Singh J, Singh N, Polskaya M, Rosenwaks Z, Poretsky L Thiazolidinediones inhibit estrogen synthesis by interfering with androgen binding to aromatase The Endocrine Society’s 90th Annual Meeting, San Francisco, CA, USA, 2008
        23. P. Taushanova, R. Konakchieva. Immunomodulation by melatonin-sensitive mechanisms of immune response and apoptosis. 12th International Symposium for Immunology of Reproduction, Varna, Bulgaria, 25-27 June 2009.
        24. Konakchieva, R, Gulenova D, Todorov P, Dimitrov Y. Cryopreservation of cord blood haematopoietic stem cells – Bulgarian exeriene. 1st Int Congres on Controversies in Crypreservation of Stem cells, Reproductive tissue &Organs. Valencia, Spain, 22-25 April 2010

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