ANNOUNCEMENT conserning a scientific seminar on 13.05.2015
May 11, 2015ANNOUNCEMENT
On the 13-th of May, at 14.00 h, in the meeting hall of IBIR, a scientific seminar will take place according to the following program:
COEVOLUTION NETWORK OF CLADE B HIV GP120 SEQUONSPresented by:
Anastas D. Pashov, Laboratory of Experimental Immunotherapy, Stephan Angelov Institute of Microbiology, BAS
The network of coevolving positions of HIV Clade B gp120 were mapped on the protein structure 2B4C using mean field direct coupling analysis (mfDCA) using multiple alignment of the Env protein from 984 isolates. After filtering for suitable entropy and gap content 327 positions remained, containing 64 sequons and 94 sequon related positions. Indications of evolutionary pressure to preserve the evolving glycan shield were observed as well as strong correlations between the majority of the sequons and the rest of the structure. Thus, although mainly a protection against neutralizing antibodies, the evolving glycan shield is bound by strong structural dependencies with the rest of the protein core. In its evolution gp120 is under a considerable pressure to reflect the changes in the N-glycosylation. We propose a map of epistatic interactions, which complements previous work on sequon evolution by expanding the molecular molecular context. It may aid the design of rational strategies for a guided HIV evolution of gp120.
Everyone is welcome!
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