• Institute of Biology and Immunology of Reproduction
      "Acad. Kiril Bratanov"

      • Research Projects

        Research Projects for the last 5 years:


        I. Bulgarian Academy of Science proprietary Budget subsidized:

        1. Project Title: "Characterization of sperm antigens with fusogenic activity in fertilization" 2007-2009
        PI: Associate Professor Dr. Margarita Mollova

        2. Project Title: "Expression and characterization of matrix metalloproteinases with a role in the processes of spermatogenesis and fertilization, 2008-2009
        PI: Assistant Professor Dr Pavel Rashev

        3. Project Title: "Studies on antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) levels in follicular fluid of infertile patients and their relationship to the outcome of assisted reproduction. Relationship between SOD and vitality of human granulosa lutein cells (GLCs)", 2009-2010
        PI: Associate Professor Dr Maria E. Ivanova

        4. Project Title: “Immuno-endocrine regulation of ovary”, 2010-2011
        PI: Assistant Professor Ivaylo Vangelov

        5. Project Title: "Regulatory mechanisms in luteinisation and apoptosis in preovulatory follicle", 2010-2011
        PI: Assistant Professor Dr Julieta Dineva

        6. Project Title: “Non-invasive test of the genetic potential of cumulus cells as biomarkers for selecting oocytes in program for in vitro fertilization”, 2010-2011.
        PI: Assistant Professor Dr Krassimira Todorova-Hayrabedyan


        II. Projects funded by NSF

        1. Project MU-K1 1306/03 "Identification and characterization of sperm molecules fusogenic activity in the interaction of gametes and their significance for fertility", 2004 - 2007, 4500 EUR
        PI: Assistant Professor Dr Julieta Dineva

        2. Project Contract № L 1407/04 "Role of regulatory T cells during HIV-1 infection and immunological recovery during HAART", 2004-2008, 15 000 lv.
        PI - Associate Professor Dr Velislava Terzieva

        3. Project Contract № L 1505/05 “Evaluation of the immunogenicity of peptides from the RD1 region of M. tuberculosis in individuals with active or latent tuberculosis infection immunized with BCG vaccine”, 2005-2010, 15 000 lv.
        Participant IBIR - Associate Professor Dr Velislava Terzieva

        4. Project B 1537/2005 “Local cellular and molecular mechanisms involved in the induction of immune tolerance during pregnancy in epitheliochorial type placenta”, 2006-2009, 26500 lv.
        PI: Professor Dr Raina Georgieva, DSc

        5. Project B1517/05 “The Importance of calcium-binding protein Secretagogin in hormone-secreting neuroendocrine cells”, 2006-2010. 20600 lv.
        PI: Assistant Professor Teodora Daneva

        6. Project B 1507/2005 “Regulatory mechanisms in luteinization and apoptosis in preovulatory follicle”, 2005-2009. 25400 lv.
        PI: Associate Professor Dr Maria E. Ivanova

        7. Project MU-B/1503/2005 “Characterization of antigens associated with ovarian autoimmunity”, 2006-2009. 9900 lv.
        PI: Assistant Professor Dr Ivaylo Vangelov

        8. Project TKB-1606 “Localization and function of stress proteins in testicular germ cells in heat-induced and spontaneous apoptosis”, 2007 - 2010., 42.000 Euro
        PI: Associate Professor Dr. Margarita Mollova

        9. Project DOO2-172/08 “New temperature-sensitive superoxide dismutase from Antarctic fungi: biotechnological study, chemical characterization and application” - a Joint project with the Institute of Microbiology-BAS, 2009-2011, IBIR - 19.530 Euro for the first 18 months.
        PI (IBIR) - Associate Professor Dr. Margarita Mollova

        10. Project DOO2-92/15.04.2009 “Preparation of research projects for the 7th Framework Programme of EU”, 2009-2010, 6.000 EUR
        PI: Associate Professor Dr. Margarita Mollova

        11. Project DOO2-50/2008 “Building Scientific Research Centre on the problems in reproductive health" under Program "Development of scientific infrastructure”, 2009- 2011, 800 000 lv.
        PI: Associate Professor Dr. Margarita Mollova



        III. Additional projects funded by contracts ministries, departments and companies in the country

        1. Project "Impact of anti-ovarian antibodies on fertility," concluded with: Medical Centre ReproBioMed, 2010-2011. (application and commercialization of scientific products)
        2. Project "Impact of anti-ovarian antibodies on fertility," concluded with: Centre for Reproductive Health "Hope", 2010-2011. (application and commercialization of scientific products)
        3. Project "Impact of anti-ovarian antibodies on fertility," concluded with: Medical Centre "Reproductive health" 2007-2011. (application and commercialization of scientific products)
        4. Project "Impact of anti-ovarian antibodies on fertility," concluded with: Medical Centre "Faith", 2007-2011. (application and commercialization of scientific products)
        5. Project "Studies on the gene regulation of Mas1, ACE2 and ACE in normal and pathological tissue from patients with breast cancer" - concluded with the private Gynaecology Clinic “Professor Hans Donat”, Magdeburg (partner organization IBIR project under 7th EU FP) and private Hospital “Tokuda”, Sofia, 2010-2011.
        PI: Associate Professor Dr Pavel Rashev



        IV. Additional projects funded contracts and programs of the EU, NATO, UNESCO and others. International Organizations

        1. PROJECT TO CALL FP7-REGPOT-2009-1 (ReProForce) "Enhancing scientific capacity of the Bulgarian Institute of Biology and Immunology of Reproduction, 2009-2013, EUR 1,500,000
        Project Coordinator: Associate Professor Dr. Margarita Mollova

        2. PROJECT TO CALL FP7-PEOPLE-2009-IEF "Effects of IL-7 and IFNa on the development of nTreg", concluded between Bulgaria (IBIR) and France (INSERM), 2011-2013
        Participant (Bulgaria): Associate Professor Dr Velislava Terzieva

        3. Participation in Project: BG051PO001/07/3.3-02/33 funded by the Operative Programme "Human Resources" of the European Social Fund “Training of PhD students in basic research skills - a prerequisite for a dynamic career in accordance with the needs of the Labour Market”, 2008 - 2010
        PI: Raya Staykova, Centre for Science Studies and History of Science.
        Participants (Bulgaria): Ph.D. Konstantin Danailov

        4. Participation in Project: BG051PO001/07/3.3-02/33 funded by the Operational Programme "Human Resources" of the European Social Fund - "Expanding the skills and qualifications of young scientists - a prerequisite for professional development in border areas between science and practice" 2010 - 2011.
        PI: Raya Staykova, Centre for Science Studies and History of Science.
        Participants (Bulgaria): Silvina Zapryanova and Alexander Kukov


        V. EBR and projects within the institute-to-institute collaboration

        1. Project "Role of spermatozoa selected proteins in fertilization," with the Institute of Genetics, Czech Academy of Sciences, 2003-2006.
        PI from IBIR: Associate Professor Dr. Margarita Mollova
        2. Project "Studies on the control mechanisms of differentiation, luteinisation and apoptosis in ovarian cells" with the Polish Academy of Sciences, Jagiellonian University, Krakow: Institute of Zoology, 2006 - 2009.
        PI from IBIR: Associate Professor Dr. M. D. Ivanova
        3. Project “Expression of genes and proteins with a role in reproduction - biomarkers for infringements” Institute of Genetics, Czech Academy of Sciences, 2007 - 2010.
        PI from IBIR: Associate Professor Dr. Margarita Mollova
        4. Project “Expression of genes and proteins with role in reproduction” with the Institute of Biotechnology, Czech Academy of Sciences, 2011 - 2013.
        PI from IBIR: Associate Professor Dr. Margarita Mollova

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