• Institute of Biology and Immunology of Reproduction
      "Acad. Kiril Bratanov"

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      • ANNOUNCEMENT

        Jan 5, 2018

        ANNOUNCEMENT

         

        On the 17-th of January 2018 in the meeting hall of IBIR, at 15.00 h, a scientific seminar will take place according to the following program:

         

        Immunity in early life:  the case of human γδ T cells

         

        Presented by:

         

        Dr David Vermijlen

        Department of Pharmacotherapy and Pharmaceutics - Institute for Medical Immunology (IMI)

        Université Libre de Bruxelles (ULB), Bruxelles

         

         

        Instead of being regarded as just an immature version of the adult immune system, the immune system in early life increasingly is being recognized as different, with a bias toward the induction of a Th2 response or of immune tolerance. Originally proposed as a hypothesis by Adrian Hayday, there is increasing evidence, including our own results, that γδ T cells are important in early life. Although in humans circulating T cells can be detected as early as 12.5 wk gestation, most information on T cells in early life, including γδ T cells, is derived from studies on cord blood at term delivery (>37 wk gestation). We found that fetal blood around midgestation (before 30 wk) contained high levels of Vγ9Vδ2 T cells. These lymphocytes expressed a semi-invariant TCR, were phosphoantigen reactive, and showed a preprogrammed effector potential, suggesting that these γδ T cells may fulfill an important role in the immunosurveillance of fetal tissues.

        Everyone is welcome! 

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