On the 21-th of February 2017 in the meeting hall of IBIR, at 12.00 h, a scientific seminar will take place according to the following program:
COMBINED APPROACH FOR IN VITRO AND IN VIVO VISUALIZATION OF INTERNALIZATION AND LOCALIZATION OF FLUORESCENT NANOPARTICLES IN TUMORS AFTER ELECTROPORATION
S. Semkova, B. Nikolova, S. Murayama, E. Stoyanova, I. Tsoneva, Zh. Zhelev, I. Aoki, R. Bakalova
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences
Since cancer is one of the leading causes of mortality, logically, the main goal of the biological and medical science is to increase the effectiveness of cancer treatment. Promising in this area are two actively investigated science directions - contemporary chemotherapy and nanoparticle-based drug delivery systems. In the last decade the theranostic strategy has become an important element of cancer treatment as it helps to develop anticancer therapeutics based on imaging and therapy (“theranostics nanoparticles”).
Nanoparticle-based drug delivery systems (nano-DDS) are constructed to deliver high local concentrations of drugs and/or contrast agents into the target locus (organs, tissues, or even cells). Designing nanocarriers, capable for selective disposition into the cancer cells and solid tumors, is an essential issue in the development of new diagnostic and therapeutic strategies in cancer. In the recent years many authors have reported the development and successful implementation of theranostic nanoparticles. In case of in vivo treatment could be achieve of a high local drug/contrast agents concentration, minimal probes leakage during transfer, biocompatibility and reduced toxicity with aim of influence on cancer at the cellular and molecular level.
Electroporation-based cancer treatment techniques are currently after active investigations in the field of drug delivery, optimization of electrical parameters and elucidation of the exact mechanisms at a molecular level. Interest are different techniques for target-specific and an increased retention of nanoparticles in solid tumors. Electro-assisted delivery and internalization is a promising approach in this direction. Electrotreatment assisted penetration, localization and retention of nanoparticles in the tumor. Improvement of existing and development of new combinations of electrochemotherapy and nanosized long-circulating drug delivery systems have the potential for future therapeutic strategy in personalized treatment of solid tumors.
Everyone is welcome!